Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.310 AlteredExpression disease BEFREE Endothelin-1 is upregulated in oral mucosal inflammation, although it has not been shown to induce pain in oral ulcers. 29518348 2018
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.020 AlteredExpression disease BEFREE And reduce the degree of edema and hyperaemia around the ulcer tissue significantly (<i>P</i> < 0.01), improve the ulcer healing probability, and reduce the level of TNF-α, VEGF levels and increase IL-2 level in the serum of rats with oral ulcers significantly (<i>P</i> < 0.01). 31049005 2019
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.020 AlteredExpression disease BEFREE And reduce the degree of edema and hyperaemia around the ulcer tissue significantly (<i>P</i> < 0.01), improve the ulcer healing probability, and reduce the level of TNF-α, VEGF levels and increase IL-2 level in the serum of rats with oral ulcers significantly (<i>P</i> < 0.01). 31049005 2019
Entrez Id: 7172
Gene Symbol: TPMT
TPMT
0.010 AlteredExpression disease BEFREE Azathioprine-induced pancytopenia with normal TPMT activity presenting with HSV oral ulcers. 30002211 2018
Entrez Id: 2023
Gene Symbol: ENO1
ENO1
0.010 AlteredExpression disease BEFREE Serum levels of IgG antibodies against alpha-enolase are increased in patients with Behçet's disease and are associated with the severity of oral ulcer, erythrocyte sedimentation rates, and C-reactive protein. 28770703 2018
Entrez Id: 8651
Gene Symbol: SOCS1
SOCS1
0.010 AlteredExpression disease BEFREE SOCS1 and SOCS 3 were also significantly upregulated in BMC from oral ulcers of BD compared with HCs (both at P = 0.0001). 25207681 2014
Entrez Id: 3082
Gene Symbol: HGF
HGF
0.010 AlteredExpression disease BEFREE To evaluate the influence of overexpression HGF on the healing of traumatic ulcer of oral mucosa of mice. 28830652 2017
Entrez Id: 9021
Gene Symbol: SOCS3
SOCS3
0.010 AlteredExpression disease BEFREE SOCS1 and SOCS 3 were also significantly upregulated in BMC from oral ulcers of BD compared with HCs (both at P = 0.0001). 25207681 2014
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.310 Therapeutic disease CTD_human Role of endothelin-1-dependent up-regulation of leptin in oral mucosal repair. 16391412 2005
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.300 Therapeutic disease CTD_human Role of endothelin-1-dependent up-regulation of leptin in oral mucosal repair. 16391412 2005
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
0.120 Biomarker disease BEFREE Other significant findings include the association between risk alleles in FCGR2A and malar rash (p=0.0031, OR 1.11, 95% CI 1.17 to 1.33), ITGAM and discoid rash (p=0.0020, OR 1.20, 95% CI 1.06 to 1.33), STAT4 and protection from oral ulcers (p=0.0027, OR 0.89, 95% CI 0.83 to 0.96) and IL21 and haematological disorder (p=0.0027, OR 1.13, 95% CI 1.04 to 1.22). 21719445 2011
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
0.120 Biomarker disease HPO
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
0.120 Biomarker disease BEFREE In contrast, STAT4 was less strongly associated with oral ulcers, a manifestation associated with milder disease. 18516230 2008
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.110 Biomarker disease HPO
Entrez Id: 5788
Gene Symbol: PTPRC
PTPRC
0.100 Biomarker disease HPO
Entrez Id: 64421
Gene Symbol: DCLRE1C
DCLRE1C
0.100 Biomarker disease HPO
Entrez Id: 715
Gene Symbol: C1R
C1R
0.100 Biomarker disease HPO
Entrez Id: 4210
Gene Symbol: MEFV
MEFV
0.100 Biomarker disease HPO
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.100 Biomarker disease HPO
Entrez Id: 3592
Gene Symbol: IL12A
IL12A
0.100 Biomarker disease HPO
Entrez Id: 847
Gene Symbol: CAT
CAT
0.100 Biomarker disease HPO
Entrez Id: 355
Gene Symbol: FAS
FAS
0.100 Biomarker disease HPO
Entrez Id: 113235
Gene Symbol: SLC46A1
SLC46A1
0.100 Biomarker disease HPO
Entrez Id: 149233
Gene Symbol: IL23R
IL23R
0.100 Biomarker disease HPO
Entrez Id: 1230
Gene Symbol: CCR1
CCR1
0.100 Biomarker disease HPO